Stereocilia displacement induced somatic motility of cochlear outer hair cells.
نویسندگان
چکیده
منابع مشابه
Stereocilia displacement induced somatic motility of cochlear outer hair cells.
Outer hair cells, isolated from mammalian cochleas, are known to respond to electrical stimulation with elongation or contraction of the cell's cylindrical soma. It is assumed that such shape changes, when driven by the cell's receptor potential in vivo, are a part of the feedback process that underlies cochlear amplification. To date it has not been possible to demonstrate somatic shape change...
متن کاملCochlear outer hair cell motility.
Normal hearing depends on sound amplification within the mammalian cochlea. The amplification, without which the auditory system is effectively deaf, can be traced to the correct functioning of a group of motile sensory hair cells, the outer hair cells of the cochlea. Acting like motor cells, outer hair cells produce forces that are driven by graded changes in membrane potential. The forces dep...
متن کاملSomatic stiffness of cochlear outer hair cells is voltage-dependent.
The mammalian cochlea depends on an amplification process for its sensitivity and frequency-resolving capability. Outer hair cells are responsible for providing this amplification. It is usually assumed that the membrane-potential-driven somatic shape changes of these cells are the basis of the amplifying process. It is of interest to see whether mechanical reactance changes of the cells might ...
متن کاملEvidence that phosphoinositides mediate motility in cochlear outer hair cells.
Cochlear outer hair cells are postulated to modulate auditory transduction by their mechanical properties which presumably are controlled by efferent neurons and regulated by the levels of intracellular calcium. In a number of biological systems these calcium levels are controlled by inositol trisphosphate (InsP3), the second messenger of the phosphoinositide cascade. We have investigated wheth...
متن کاملA model of cochlear mechanics with outer hair cell motility.
The outer hair cell (OHC) is known to have the ability to change its length in response to voltage changes across its membrane. The apparent function of this OHC motility is to enhance the tuning of the basilar membrane. The model presented in this paper represents the displacement-to-voltage and voltage-to-displacement transducers of the OHC explicitly, each as low-pass filter functions. The m...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1993
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.90.18.8347